Lab Case 46 – Interpretation

70 year old patient critically unwell, with life threatening hyperkalaemia requiring non invasive cardiac monitoring in resuscitation bay and urgent reduction of potassium.

1. Severe life threatening hyperkalaemia

high anion gap metabolic acidosis with additional respiratory acidosis (expected CO2 33)

acute renal failure

osmolality 313 with glucose 40 – indicates likely HHS (using uncorrected sodium)

pseudohyponatraemia (corrected 134)

hypochloraemia

Very high lactate – critically unwell with poor end organ perfusion and shock

2. HHS – precipitants include infection (UTI, pneumonia, cellulitis, septic knee, sepsis), medications(digoxin, diuretics, other), non compliance, underlying disease (MI, CVA, PE, mesenteric thrombosis), alcohol abuse

HAGMA – Acute renal failure, sepsis, shock (consider cardiogenic shock – bradycardia, hypotension), consider toxins

ARF – fluid depletion (large pre renal component – severe fluid depletion >10 litres deficit in HHS), ATN (fluid loss, direct insult, hypoxic injury), consider obstructive cause

Hyperkalaemia – ARF, digoxin related, diuretic use (thiazides)

Respiratory acidosis – aspiration, pneumonia, PE, altered GCS

3. First priority – ECG, confirm hyperkalaemia and treat (Insulin, Ca gluconate, Ca resonium, Salbutamol nebs, ??dialysis), check for digoxin (toxicity) prior to Calcium administration.

HHS

a. fluid resuscitation (2-3 litres in the first 2-3 hours, will require up to 10 litres over 1-2 days – choice of fluid??), followed by inotropes and invasive monitoring

b. Electrolytes – monitor potassium, check Ca, Mg, PO4, consider choice of fluid according to corrected Na after initial resuscitation

c. Insulin therapy – 0.1 U/kg/hr with aim to reduce glucose by 2-3 mmol/hr. Will require insulin bolus initially to reduce potassium

d. Seek and treat underlying cause

These patients usually require VTE prophylaxis, consider arterial / venous thrombosis in this setting.

4. Complications

Usually result from inadequate treatment and include mesenteric artery occlusion, AMI, VTE, DIC, rhabdomyolysis

Too much fluid can cause cerebral oedema and ARDS

 

 

 

 

VN:F [1.9.22_1171]
Rate this post
Rating: 3.0/5 (2 votes cast)
Lab Case 46 - Interpretation, 3.0 out of 5 based on 2 ratings