The daily educational pearl – Sweet syndrome

Sweet syndrome (acute febrile neutrophilic dermatosis)

= tender, red-to-purple papules and nodules + fever + peripheral neutrophilia

The skin lesions display pathergy or Köebner phenomenon – lesions occur in areas of minor trauma, such as sites of scratches, bites

 It is usually preceded by an URTI, vaccination or GIT infections, but can also occur secondary to medications and in pregnancy. Frequently associated with underlying malignancy (especially haematological) or other immunodeficiency – occurrence of Sweet syndrome should prompt workup for underlying cause.
Steroids are very effective for the skin lesions, but the underlying cause should be treated as well.

One thought on “The daily educational pearl – Sweet syndrome

  1. Thank you so much for blogging about Sweet’s Syndrome. While Prednisone (corticosteroids) are very effective, they are not adequate for long-term use and difficult to impossible to discontinue without other options like immuno-suppressants.

    We’re educating the medical community and the public so people don’t have to suffer so long without diagnosis or proper treatment.

    Sweet’s Syndrome Awareness site:

    My blog:

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