50 year old male presents to ED after a heroin OD.

The patient had CPR on scene and responded to imi naloxone given by the ambulance. On arrival to ED BP 120/80 HR 75 Sats 93%RA Apyrexial RR6 and GCS 12.

VBG

pH 7.17                                                 BSL 8.4

pCO2 84mmHg                                     Lactate 2.2

pO2 28mmHg

HCO3 29mmol/l

B/E -3

1. Describe and Interpret the VBG
2. Discuss the pharmacokinetics and dynamics of naloxone
3. Discuss the management of opiod overdose