A 45-year-old man presents with vomiting and numbness on his fingers . He has CML and he is on chemotherapy. His blood biochemistry showed the following:

Na = 130 mmol/L

K = 6.8 mmol/L

Cl = 101 mmol/L

HCO3 = 14 mmol/L

Urea = 33.6 mmol/L

Creatinine = 283 umol/L

Calcium (Total) = 1.02 mmol/L

Phosphate = 4.6 mmol/L

Mg = 1.5 mmol/L

Albumin = 32 mmol/L

LDH = 986 IU/L

Uric acid = 2.1 mmol/L

Questions:

1. What are the main abnormalities on these results?
2. What is the most likely cause of these abnormalities?
3. How will you manage this condition?